Als And The Cause And Effects

Als And The Cause And Effects

Spencer andassociates (cited in Rowland, 1991, p. Finally, the heat shock protein, ubiquitin, mayassociate with intermediate filament inclusion bodies to form eitheraggregates or skein-like cytoplasmic arrays. The study identified a basic amino acid, ß-N-methylamino-L-alanine (BMAA),with the potential to act as an excitatory neurotoxin. (cited in Swash & Schwartz, 1992, p. 1 )observed that cooked food has fairly low quantities of active BMAA. Such changes, however, are highly variable. Journal of the Neurological Sciences, 124 Supplement: 38- 51.Rowland, L. Perhaps the most innovative hypothesis for ALS pathogenesis, however,involves genetics. Patten et al. 4-13) found that patients with bulbar involvementsurvived for a mean period of 2.2 years; median survival for all ALS casesis 3-4 years. Technologicaladvances in molecular biology have provided researchers with innovativeapproaches to the disease. 14-15) consideredhumoral immune mechanisms. In addition,various other studies have made similar observations (e.g., Mulder andHoward 1976; Engel et al. Ratherit results from an apparent gain of function. P. This free radical, which is generated during normal oxidativereactions, is dismutated to form hydrogen peroxide and oxygen. F. Magnetic resonance imaging studies havedemonstrated high intensity lesions widely distributed within the centralnervous system white matter. About a third ofpatients present with bulbar symptoms. These can include the spinocerebellar pathways andnuclei, the frontal cortex, and the substantia nigra (Swash & Schwartz,1992, pp. Given the inherent heterogeneity of ALS, it seems likely thatmultiple pathologic processes are involved. For example, ALSpatients' skeletal muscle may exhibit signs of denervation andreinnervation. However, there issome doubt as to whether the compound is actually capable of inducingneurologic degeneration. G.; Engelhardt, J. Various synonyms for amyotrophic lateral sclerosis (ALS) include LouGehrig's disease, Charcot...